Pathophysiologic mechanisms of acute graft-vs.-host disease
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چکیده
منابع مشابه
Pathogenic mechanisms of Acute Graft versus Host Disease
Graft Versus Host Disease (GVHD) is a life threatening complication of allogeneic bone marrow transplantation (BMT), an important therapy for a number of hematologic diseases. In its acute phase, GVHD involves activation of proinflammatory cytokine cascades and immune effector cells that result in target tissue damage (1, 2). Multiple cellular populations and cytokines interact in a complex pro...
متن کاملAcute graft versus host disease
Acute graft-versus-host disease (GVHD) occurs after allogeneic hematopoietic stem cell transplant and is a reaction of donor immune cells against host tissues. Activated donor T cells damage host epithelial cells after an inflammatory cascade that begins with the preparative regimen. About 35%-50% of hematopoietic stem cell transplant (HSCT) recipients will develop acute GVHD. The exact risk is...
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Graft-versus-host disease (GVHD) has been the primary limitation to the wider application of allogeneic bone marrow transplantation (BMT). The immunobiology of acute GVHD is complex and can be conceptualized to be a three-step process. In step 1, the conditioning regimen (irradiation and/or chemotherapy) leads to the damage and activation of host tissues and induces the secretion of inflammator...
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(1844 articles) Transplantation (4939 articles) Immunobiology Articles on similar topics can be found in the following Blood collections http://bloodjournal.hematologylibrary.org/site/misc/rights.xhtml#repub_requests Information about reproducing this article in parts or in its entirety may be found online at: http://bloodjournal.hematologylibrary.org/site/misc/rights.xhtml#reprints Infor...
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Acute graft-versus-host disease (GvHD) is a frequent complication of allogeneic haemopoietic stem cell transplantation (HSCT) and donor lymphocyte infusions (DLI). Its incidence and severity depends on several factors, such as prophylaxis method, donor/recipient matching, intensity of the conditioning regimen and composition of the graft. Significant progress has been made in recent years in un...
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ژورنال
عنوان ژورنال: Biology of Blood and Marrow Transplantation
سال: 1999
ISSN: 1083-8791
DOI: 10.1016/s1083-8791(99)70011-x