Pathomorphological features and mast cell count in canine visceral hemangiosarcomas

Visceral hemangiosarcoma were analyzed at the Department of Veterinary Pathology Faculty Medicine, University Zagreb, over a 5-year period. From total 52 tumor masses in 31 dogs, histological growth patterns (cavernous, capillary or solid) and amount supporting stroma evaluated. Additionally, sections stained with toluidine blue for purpose mast cell detection their number was determined parenchyma, edges. The average age affected animals 10 years, males predominated, tumors occurred most frequently cross breeds, German Shepherd dogs Labrador Retrievers. highest visceral found spleen (27/52). common pattern solely cavernous mixture solid different proportions. Mast cells 44/52 (84.6%) hemangiosarcomas. A smaller higher not significantly associated pattern, but there positive correlation between MCC - parenchyma (rs = 0.28, P<0.05), + edges 0.74, P<0.05) MCC- stroma+edges 0.30, all examined tumors. In splenic tumors, only significant P 0.68 P<0.05). These results suggest count more developed stromal components canine hemangiosarcomas, certainly indicate need further research on role factors they release development progression