Pathology of radiation myelopathy

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Pathology of radiation myelopathy.

After nothing the rarity of papers describing the pathology of delayed radiation necrosis of the spinal cord, the clinical and pathological findings from four cases are presented. The main pathological features are asymmetric demyelination of the lateral columns and to a lesser degree the posterior and anterior columns of white matter, with coagulative necrosis at the level of irradiation which...

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[Radiation myelopathy].

Five cases of radiation myelopathy were found in a total of 10,000 cases given radiotherapy from 1968 to 1977. The clinical presentation and treatment details including the total dose, treatment volume, number of fractionations, overall time, and the RET value at the spinal cord were calculated and compared with other reports on this subject. The total number of fractionations ranged from 20 to...

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MR imaging in radiation myelopathy.

PURPOSE Using MR imaging, we assessed the signal, size, and enhancing characteristics of the cervical cord in patients in whom radiation myelopathy developed after radiotherapy for nasopharyngeal carcinoma. PATIENTS AND METHODS Ten patients, 3 men and 7 women, aged from 32 to 77 years, were included. MR imaging was performed 1 to 53 months after clinical manifestations of myelopathy. RESULT...

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Ultrastructural pathology of nerve fibers in calcium-induced myelopathy.

Calcium has been proposed as a mediator of nerve fiber degeneration following traumatic injury of the spinal cord. It induces a spongy, necrotizing myelopathy similar in its evolution to that observed in experimental spinal cord trauma. The current study was undertaken to determine the ultrastructural changes in the central nervous system (CNS) nerve fibers associated with calcium-induced myelo...

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Radiation myelopathy of cervical spinal cord simulating intramedullary neoplasm.

Radiation myelopathy is a well-known complication of irradiation therapy of neoplasms in the vicinity of the spinal cord. Most earlier authors have stressed the association of a normal myelogram and normal CSF protein level with this condition. One case of radiation myelopathy with a myelogram simulating intramedullary neoplasm and with extremely high CSF protein concentration is presented. Six...

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ژورنال

عنوان ژورنال: Journal of Neurology, Neurosurgery & Psychiatry

سال: 1972

ISSN: 0022-3050

DOI: 10.1136/jnnp.35.6.888