Pathological role of fibroblast-like synoviocytes in charcot neuroarthropathy
نویسندگان
چکیده
منابع مشابه
Evaluation of tendon healing using fibroblast like synoviocytes in rabbits: A biomechanical study
Tendon never restores the complete biological and mechanical properties after healing. Several techniques are available for tissue-engineered biological augmentation for tendon healing like stem cells. Recently, synovium has been investigated as a source of cells for tissue engineering. In the present study, we investigated potentials of fibroblast like synoviocytes (FLSs) in tendon healing. Si...
متن کاملSimvastatin Induces Apoptosis of Fibroblast-Like Synoviocytes
BACKGROUND Statins (3-Hydroxy-3-methylglutaryl-CoA reductase inhibitors) exert favorable effects on lipoprotein metabolism, but appeared to possess anti-inflammatory properties among others, as suggested by their ability to inhibit collagen-induced arthritis in mice. Their activity in fibroblast-like synovial cells (FLS) has not yet been studied. OBJECTIVES To evaluate the effect of varying d...
متن کاملIn Vitro Evaluation of Equine Fibroblast-Like Synoviocytes Viability Treated with Doxycycline
Objective- The purpose of present study was to investigate the viability of equine fibroblast-like synoviocytes (FLSs) treated with doxycycline. Design- Experimental study. Sample population- FLSs from metacarpophalangeal joints of six skeletally mature horses. Methods- FLSs were established from synovial fluids of healthy joints. The cells were treated with different concentr...
متن کاملBisphosphonates for the treatment of Charcot neuroarthropathy.
Excess osteoclastic activity is believed to be responsible for the destruction in Charcot neuropathic joint disease. By intervening early in the destructive process, it may be possible to halt the progression toward the devastating bone and joint deformity responsible for morbidity in Charcot feet. This retrospective study evaluated the effects of the bisphosphonate pamidronate on associated si...
متن کاملPathophysiology of Diabetes and Charcot Neuroarthropathy
This chapter serves as a primer on the pathophysiology of both diabetes mellitus and Charcot arthropathy for the orthopedic surgeon. In regards to diabetes we will focus on the pathophysiology as it pertains to musculoskeletal manifestations of the disease process. The pathophysiology that underlies the development of diabetes is beyond the scope of this chapter. We will discuss both the histor...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Orthopaedic Research
سال: 2015
ISSN: 0736-0266
DOI: 10.1002/jor.22989