منابع مشابه
A model for emergence of high pathogenicity avian influenza virus from outbreaks with low pathogenicity avian influenza virus
In this article, we establish a mathematical model for emergence of high pathogenicity avian influenza (HPAI) viruses from outbreaks of low pathogenicity avian influenza (LPAI) A viruses (H5N2). The model is based on traditional mathematical epidemiology models and experiment evidences. It contains several submodels which are traditional SEIR models or SIR models. The experiments in [25] provid...
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Chicken interferon-alpha administered perorally in drinking water acts on the oropharyngeal mucosal system as an adjuvant that causes chickens to rapidly seroconvert after natural infection by low-pathogenicity Influenza virus. These chickens, termed super sentinels, can serve as sensitive early detectors of clinically inapparent infections.
متن کاملPathogenicity of the Novel A/H7N9 Influenza Virus in Mice
UNLABELLED A novel avian-origin influenza A/H7N9 virus infecting humans was first identified in March 2013 and, as of 30 May 2013, has caused 132 human infections leading to 33 deaths. Phylogenetic studies suggest that this virus is a reassortant, with the surface hemagglutinin (HA) and neuraminidase (NA) genes being derived from duck and wild-bird viruses, respectively, while the six "internal...
متن کاملExperimental Study on the Pathogenicity of Avian Influenza A/Ch/It/5093/99(H7N1) Virus in Chicken
In this study, the pathogenicity of A/Ch/It/5093/1999 H7N1 which had been isolated from chicken during the outbreak in Italy was assessed in chicken by experimental infection virus. Ten SPF chickens of four week-old were inoculated with this virus, and five chickens were inoculated with uninfected allantoic fluid. For determination of virus shedding, oropharyngeal and cloacal swabs were taken f...
متن کاملPAR1 contributes to influenza A virus pathogenicity in mice.
Influenza causes substantial morbidity and mortality, and highly pathogenic and drug-resistant strains are likely to emerge in the future. Protease-activated receptor 1 (PAR1) is a thrombin-activated receptor that contributes to inflammatory responses at mucosal surfaces. The role of PAR1 in pathogenesis of virus infections is unknown. Here, we demonstrate that PAR1 contributed to the deleterio...
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ژورنال
عنوان ژورنال: Microbiological Reviews
سال: 1980
ISSN: 0146-0749
DOI: 10.1128/mr.44.2.303-330.1980