Pathogen–Host Cell Molecular Interactions

Molecular interactions in cell adhesion

Cell adhesions consist of multimolecular protein complexes of transmembrane adhesion receptors anchoring intracellular cytoskeletal structural proteins and signal transduction molecules. Recent advances reveal that components of cell adhesion complexes display multiple interactions and functions, which cooperate to mediate both cell adhesion and signaling. Cell-matrix and cell-cell adhesions ca...

Spatiotemporal control of cell–cell reversible interactions using molecular engineering

Manipulation of cell-cell interactions has potential applications in basic research and cell-based therapy. Herein, using a combination of metabolic glycan labelling and bio-orthogonal click reaction, we engineer cell membranes with β-cyclodextrin and subsequently manipulate cell behaviours via photo-responsive host-guest recognition. With this methodology, we demonstrate reversible manipulatio...

Pathogen–Host Cell Molecular Interactions Knowledge and Challenge

tainly turn out more complex than had been hoped. life. The scientific community has missed the opportunity to eradicate or even control the most dangerous of Nevertheless, the interaction of large-T with p53 is now these infectious diseases. As Leonardo da Vinci said: known not only to play a crucial role in SV40-mediated " Iron rusts from disuse, stagnant water loses its purity oncogenesis, b...

Engineered Aptamers to Probe Molecular Interactions on the Cell Surface

Significant progress has been made in understanding the nature of molecular interactions on the cell membrane. To decipher such interactions, molecular scaffolds can be engineered as a tool to modulate these events as they occur on the cell membrane. To guarantee reliability, scaffolds that function as modulators of cell membrane events must be coupled to a targeting moiety with superior chemic...

Molecular Plant-Microbe Interactions