Pathogenetic mechanisms of antiphospholipid antibody production in antiphospholipid syndrome

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ANTIPHOSPHOLIPID ANTIBODY SYNDROME-A CASE OF AORTIC VALVE INSUFFICIENCY

A 31 year old woman was hospitalized for evaluation of aortic valve insufficiency and her present cardiac status. Clinical and paraclinical findings strongly suggested the presence of a collagen vascular inflammatory processprecisely, the antiphospholipid antibody syndrome (APS), with systemic lupus erythematosus as the underlying disease.

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Treatment of antiphospholipid antibody syndrome

Antiphospholipid antibody syndrome (APS) is a systemic autoimmune disease with thrombotic predilection resulting in vascular thrombotic events and obstetric complications. Management of APS focuses on anticoagulation; however, despite the solid evidence suggesting that this is the best treatment option available, a lot of debate persists regarding the intensity and duration of anticoagulation n...

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Pathophysiological mechanisms in antiphospholipid syndrome

Antiphospholipid syndrome (APS) is a systemic autoimmune disease characterized by recurrent thrombosis and fetal loss in the presence of persistently positive antiphospholipid (aPL) antibodies (Abs) including lupus anticoagulant (LAC), IgG/IgM anticardiolipin (aCL) Abs and anti-b2glycoprotein I (b 2 GPI) Abs [1–3]. aPL Abs are a heterogenous group of autoantibodies that react to phospholipids (...

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Los pacientes afectos de síndrome antifosfolipídico (SAF) presentan un riesgo aumentado de padecer trombosis venosas y arteriales, pérdidas fetales recurrentes y/o trombocitopenia. Estas manifestacions clínicas se asocian con la presencia de anticuerpos antifosfolipídicos (AAF), entre los que se incluyen los anticuerpos anticardiolipina (aCL) y el anticoagulante lúpico (AL). A pesar de la estre...

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ژورنال

عنوان ژورنال: World Journal of Rheumatology

سال: 2015

ISSN: 2220-3214

DOI: 10.5499/wjr.v5.i2.59