Pathogen infection in Alzheimer’s disease: pathophysiology and therapeutic strategies

Biofilms in chronic rhinosinusitis: Pathophysiology and therapeutic strategies

Background There is increasing evidence that biofilms are critical to the pathophysiology of chronic infections including chronic rhinosinusitis (CRS). Until relatively recently, our understanding of biofilms was limited. Recent advances in methods for biofilm identification and molecular biology have offered new insights into the role of biofilms in CRS. With these insights, investigators have...

Diabetic Kidney Disease: Pathophysiology and Therapeutic Targets

Diabetes is a worldwide epidemic that has led to a rise in diabetic kidney disease (DKD). Over the past two decades, there has been significant clarification of the various pathways implicated in the pathogenesis of DKD. Nonetheless, very little has changed in the way clinicians manage patients with this disorder. Indeed, treatment is primarily centered on controlling hyperglycemia and hyperten...

Alzheimer's Disease: Pathophysiology, Hypotheses and Treatment Strategies

1 © Under License of Creative Commons Attribution 3.0 License | This article is available from: www.psychopathology.imedpub.com Alzheimer's disease (AD) is an irreversible, progressive neurodegenerative disorder. One new case of AD is expected to be developed every 33 seconds. So, about million new cases will be developed per year and the total estimated prevalence is expected to reach 13.8 mil...

Does Fungal Infection Cause Alzheimers?

White Matter Injury after Intracerebral Hemorrhage: Pathophysiology and Therapeutic Strategies

Intracerebral hemorrhage (ICH) accounts for 10%-30% of all types of stroke. Bleeding within the brain parenchyma causes gray matter (GM) destruction as well as proximal or distal white matter (WM) injury (WMI) due to complex pathophysiological mechanisms. Because WM has a distinct cellular architecture, blood supply pattern and corresponding function, and its response to stroke may vary from th...