Pathogen inactivation. New progress

Pathogen inactivation: a new paradigm for preventing transfusion-transmitted infections.

Remarkable improvements have been made in blood safety since the onset of the HIV epidemic. However, the current paradigm does not prevent all transfusion-transmitted infections and is reactive to new agents, thus accepting that some patients may be harmed before preventive measures are introduced. Several methods are now available that selectively damage DNA and RNA, thus inactivating pathogen...

Pathogen Inactivation: Prospects and Pitfalls

Submit Manuscript | http://medcraveonline.com have proven to be effective against numerous bacteria, viruses, and parasites. Two main systems have emerged to treat platelet concentrates: treatment with psoralen ultraviolet A (UVA) light and treatment with riboflavin (vitamin B2) plus ultraviolet B (UVB) light, both targeting the nucleic acids of pathogens. The ability of the Mirasol PRT system ...

Pathogen inactivation: coming of age.

PURPOSE OF REVIEW In the past 20 years, several pathogen inactivation technologies have been developed to be applied to blood components. This review is intended to summarize the data currently available about the technologies and the clinical use of products inactivated by those techniques. RECENT FINDINGS Technologies for inactivating pathogens in plasma and platelets are available, and are...

Photodynamic Inactivation of Food Pathogen Listeria monocytogenes

The aim of this study is to examine the possibility to inactivate food pathogen Listeria monocytogenes by nonthermal antimicrobial treatment – photosensitization. L. monocytogenes was incubated with 5-aminolevulinic acid (ALA) (7.5 mM) for 0–2 h to produce endogenous photosensitizers and then illuminated with visible light. The LED-based light source used for the illumination of L. monocytogene...

Positively Charged Porphyrins: a New Series of Photosensitizers for Pathogen Inactivation in Red Blood Cell Concentrates