PATH-06. SURVIVAL ANALYSIS FOR ADULT MIDLINE GLIOMA: DO ADULT MIDLINE GLIOMAS WITH THE H3 K27M MUTATION REALLY HAVE POOR PROGNOSIS?

Abstract PURPOSE Since it is known that midline located glioma with H3K27 mutation in children has a disastrous prognosis, 2016 WHO classification, these tumors were defined as diffuse (DMG) and classified grade IV. A lot of papers about pediatric DMG have been published, but there are not many adult DMG. In this study, we aimed to identify factors affecting the prognosis glioma. This first paper study according histological largest investigate survival METHODS We reviewed chart patients diagnosed H3K27M after undergoing resection or biopsy among who visited our institution between January 2010 December 2020. Survival analysis was performed tumor location, grading, Karnofsky Performance Scale (KPS), age. RESULTS Among 125 gliomas identified, 45 (36.0%) had mutation. As result on gliomas, low grade, KPS ≥ 80, age ≤ 60 showed significantly better survival. After adjusting for age, difference wildtype group significant. DMG, total resection, concurrent chemoradiation therapy CONCLUSION glioma, due observed children. The determined by KPS, extent resection. Therefore, current which classifies all mutant IV regardless diagnoses, suitable adults.