Patched regulates Smoothened trafficking using lipoprotein-derived lipids
نویسندگان
چکیده
منابع مشابه
Patched regulates Smoothened trafficking using lipoprotein-derived lipids.
Hedgehog (Hh) is a lipoprotein-borne ligand that regulates both patterning and proliferation in a wide variety of vertebrate and invertebrate tissues. When Hh is absent, its receptor Patched (Ptc) represses Smoothened (Smo) signaling by an unknown catalytic mechanism that correlates with reduced Smo levels on the basolateral membrane. Ptc contains a sterol-sensing domain and is similar to the N...
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The Hedgehog (Hh) family of signaling molecules function as organizers in many morphogenetic processes. Hh signaling requires cholesterol in both signal-generating and -receiving cells, and it requires the tumor suppressor Patched (Ptc) in receiving cells in which it plays a negative role. Ptc both blocks the Hh pathway and limits the spread of Hh. Sequence analysis suggests that it has 12 tran...
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ژورنال
عنوان ژورنال: Development
سال: 2009
ISSN: 1477-9129,0950-1991
DOI: 10.1242/dev.041392