Passive control of temperature distribution in cancerous tissue during photothermal therapy using optical phase change nanomaterials

Thermal therapy is a very promising alternative treatment for benign tumor, in which the temperature control key issue to avoid unwanted thermal damage of healthy tissue. However, active methods usually require assistance real-time and accurate monitoring devices. Even though, lag inevitable. Therefore, present work, passive method proposed improve uniformity distribution inside tumorous tissue during laser induced (LITT). Optical phase change nanoparticles (O-PCNPs) are utilized replace commonly used noble metal enhance adjust localized light absorption tumor. In early stage LITT, O-PCNPs specific rate targeted region. after local reaches certain level (phase transition temperature), convert from amorphous state crystalline state. By carefully selecting size, shape, wavelength, cross section could drop dramatically transition. high zone increasing reduces due reduction heat generation rate. On contrary, rises low since more energy transferred deeper results show that SiO2@VO2 nanoshells can be applied as contrast agents tumor LITT.