Particle Scale Insights into a KG-Pharma RoTab Tablet Press Feed-Frame System Using the Discrete Element Method (DEM) Modeling

In the pharmaceutical industry, tablets are a common dosage form. As part of manufacturing process, powder in tablet press passes through feeding system called feed-frame before reaching die cavity. Under different conditions (e.g., paddle speed, turret speed), issues such as segregation blend components, over lubrication, and drug particle attrition often occur feed-frame, which affect final product quality. Therefore, developing particle-scale understanding behavior is essential. This paper used discrete element method (DEM) to study flow kg-pharma RoTab press. Simulation results show that an increase speed has less effect on mass than reduces increases variability mass. The API content small, but large speeds exacerbate components feed frame, traveled distance, shear work, torque wheel, thereby increasing lubrication attrition. However, mean residence time particles prevents at low speeds. Increasing mass, torque, time. Although can effectively prevent short times not conducive mixing excipients leading higher variability. only gives us particle-level insight into process also be inform optimize design experimental studies.