Paroxysmal cold hemoglobinuria: a unique constellation of peripheral smear findings
نویسندگان
چکیده
منابع مشابه
[An adult case of idiopathic chronic paroxysmal cold hemoglobinuria].
概要 慢 性経過 を示 した特発 性発作性 寒冷血 色素尿症 の1成 人例を報 告 し,文 献 的考察 を加 え た.症 例 は41才,男 性.1978年 冬期,先 行す る熱性疾 患を伴 わず,寒 冷に曝露 した後暗 褐色尿 に気 付 き,以 後毎年同 様 の症状 を繰 り返 すため, 1984年1月 精査 目的にて 当科 入院.貧 血 な し, 肝脾 腫 な し.入 院時検査 所見 で,ヘ モ グロ ビン尿(+), Ehrlich指 試験(+), Rosenbach試 験 (+), Donath-Landsteiner試 験(+),抗 体価4倍 で あ り発 作性寒冷 血色素 尿症 と診 断 した.血 清梅 毒反応(-), TPHA(-)で,血 清抗体価 は マイ コプラス マ,ム ンプス,麻 疹,単 純ヘ ル ペス, EBウ イル スいずれ も陰性 ない し低値 を示 した.経...
متن کاملCase report: paroxysmal cold hemoglobinuria presenting during pregnancy
BACKGROUND Paroxysmal cold hemoglobinuria is caused by a biphasic IgG autoantibody that triggers complement-mediated intravascular hemolysis. Paroxysmal cold hemoglobinuria has not previously been reported to occur in association with pregnancy. CASE PRESENTATION We report a case of an 18 year old female who presented in early pregnancy with acute hemolytic anemia and a positive Donath-Landst...
متن کاملErythrophagocytosis in Peripheral Blood Smear of a Patient with Urinary Tract Infection
Erythrophagocytosis refers to the removal of old and damaged red blood cells by leukocytes and macrophages. Observation of erythrophagocytosis in peripheral blood smear is a rare phenomenon that is mostly observed in paroxysmal cold hemoglobinuria and sporadically in some other pathological conditions. Here, we report a case of erythrophagocytosis by monocyte in peripheral blood of a patient wi...
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Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hematologic disorder that manifests with hemolytic anemia, thrombosis, and peripheral blood cytopenias.Acute abdominal pain is one of the PNH clinical manifestations due to venous thrombosis of intra-abdominal sites including hepatic, portal, mesenteric, and splenic veins.Eculizumaband allogeneic bone marrow transplantation (BMT) arethe only w...
متن کاملParoxysmal nocturnal hemoglobinuria.
Paroxysmal Nocturnal Hemoglobinuria (PNH) literally means to have episodes of hemoglobin in the urine during the night. It is a Coomb's negative rare hemolytic disorder characterized by non-malignant clonal expansion of haemopoietic stem cells due to acquired genetic mutations. A 30 years old male patient presented with 5 years history of transfusion dependent anemia with intermittent episodes ...
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ژورنال
عنوان ژورنال: Blood
سال: 2020
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.2019003989