Parenteral Nutrition Decreases Paneth Cell Function and Intestinal Bactericidal Activity While Increasing Susceptibility to Bacterial Enteroinvasion
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چکیده
منابع مشابه
tmRNA decreases the bactericidal activity of aminoglycosides and the susceptibility to inhibitors of cell wall synthesis.
Trans-translation is a process that recycles ribosomes stalled on problematic mRNAs. tmRNA, coded by the DeltassrA gene, is a major component of trans-translation. Bacteria lacking tmRNA are more sensitive to several inhibitors of protein synthesis when compared to a wild type strain. We measured bacterial growth of the DeltassrA and wild type strains in Escherichia coli in the presence of 14 a...
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ypical G-protein–coupled receptors (GPCRs), upon Tspecific ligand binding, initiate intracellular signaling by activating an immediately downstream trimeric G-protein complex consisting of a, b, and g subunits. Dissociation of the guanosine triphosphate–bound a subunit from b and g subunits triggers intracellular signaling. Intestinal epithelial GPCRs may respond to various gastrointestinal gro...
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Crohn's disease (CD) represents a chronic inflammatory disorder of the intestinal tract. Several susceptibility genes have been linked to CD, though their precise role in the pathogenesis of this disorder remains unclear. Immunity-related GTPase M (IRGM) is an established risk allele in CD. We have shown previously that conventionally raised (CV) mice lacking the IRGM ortholog, Irgm1 exhibit ab...
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ژورنال
عنوان ژورنال: Journal of Parenteral and Enteral Nutrition
سال: 2013
ISSN: 0148-6071,1941-2444
DOI: 10.1177/0148607113497514