Parameter Estimation in Biochemical Pathways: A Comparison of Global Optimization Methods
نویسندگان
چکیده
منابع مشابه
Parameter estimation in biochemical pathways: a comparison of global optimization methods.
Here we address the problem of parameter estimation (inverse problem) of nonlinear dynamic biochemical pathways. This problem is stated as a nonlinear programming (NLP) problem subject to nonlinear differential-algebraic constraints. These problems are known to be frequently ill-conditioned and multimodal. Thus, traditional (gradient-based) local optimization methods fail to arrive at satisfact...
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ژورنال
عنوان ژورنال: Genome Research
سال: 2003
ISSN: 1088-9051
DOI: 10.1101/gr.1262503