Parainfluenza Virus Type 3 Co-infection with Other Respiratory Pathogens Among Hospitalized Children with Acute Respiratory Infections in Wuhan, China

Background: Bacterial and viral co-infections are increasingly recognized as the cause of Acute Respiratory Infection (ARI). The role co-infection in ARI patients with Parainfluenza Virus type 3 (PIV3) infection is unclear. Objectives: This study aimed to determine prevalence PIV3 hospitalized children assess co-infections' infections. Methods: Between January 2018 December 2021, were confirmed have a via throat swabs or nasopharyngeal aspirates. Some digital clinical data analyzed, including demographic, epidemiological, diagnostic, laboratory data. Results: During period from 2,539 caused by PIV3. Of them, 34.0% had other pathogens, 2.4% more than two pathogens. Mycoplasma pneumoniae was most common co-infecting pathogen (71.3%), followed bacteria (13.3%) viruses (8.2%). A significantly higher proportion M. found girls (χ2 = 19.233, P < 0.001). Co-infections observed principally aged 1 – 2 years 202.130, In contrast, (56.3%) bacterial (66.1%) occurred mainly younger one year. diagnosis single included pneumonia (41.2%), bronchitis (39.9%), upper respiratory tract infections (15.0%), laryngitis (3.9%), which distinguished those 16.424, 0.001) pathogens 11.687, 0.010). any not associated admissions intensive care units ventilator support. However, mean hospitalization (t 2.367, 0.018), 2.402, 0.016), 2.827, 0.006) infection. Conclusions: virus frequently occurs epidemiological characteristics different differed. co-infections, lengthened hospitalization. increased severity worsened symptoms.