Paradigm shifts in understanding equine laminitis
نویسندگان
چکیده
منابع مشابه
Equine Laminitis: A Revised Pathophysiology
Vasodilation precedes the development of carbohydrate overload laminitis. Circulating laminitis trigger factors activate lamellar enzymes, which lyse the attachments between the distal phalanx and the inner hoof wall. The clinical signs of laminitis occur when the lamellar architecture disintegrates. The amount of pain correlates with the extent of lamellar pathology. A substance produced by St...
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Over the past 20 yr, extensive research efforts as well as clinical experience has greatly increased our knowledge base of equine laminitis. Our present understanding of the disease is that there is failure of the lamellar attachment between the distal phalanx and hoof wall. This, in turn, initiates a sequence of events ranging from no permanent structural damage to loss of the hoof capsule. Af...
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Laminitis is a common debilitating disease in horses that involves painful disruption of the lamellar dermo-epidermal junction within the hoof. This condition is often refractory to conventional anti-inflammatory analgesia and results in unremitting pain, which in severe cases requires euthanasia. The mechanisms underlying pain in laminitis were investigated using quantification of behavioural ...
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Although much has been written about laminitis in the context of its association with inflammatory processes, recognition is growing that most cases of laminitis examined by veterinarians in private practice are those associated with pasture grazing, obesity, and insulin resistance (IR). The term 'endocrinopathic laminitis' has been adopted to classify the instances of laminitis in which the or...
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Chronic equine laminitis causes persistent pain and lameness in affected animals and often necessitates euthanasia when pain management strategies become ineffective. Published studies as well as anecdotal reports suggest that this chronic inflammatory disease is associated with systemic alterations in immune responsiveness, perhaps involving an autoimmune component. We investigated this broad ...
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ژورنال
عنوان ژورنال: The Veterinary Journal
سال: 2018
ISSN: 1090-0233
DOI: 10.1016/j.tvjl.2017.11.011