Paracetamol (Acetaminophen): mechanisms of action
نویسندگان
چکیده
منابع مشابه
Paracetamol (Acetaminophen): mechanisms of action.
Paracetamol has a central analgesic effect that is mediated through activation of descending serotonergic pathways. Debate exists about its primary site of action, which may be inhibition of prostaglandin (PG) synthesis or through an active metabolite influencing cannabinoid receptors. Prostaglandin H(2) synthetase (PGHS) is the enzyme responsible for metabolism of arachidonic acid to the unsta...
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BACKGROUND Paracetamol (acetaminophen) is the most widely used non-prescription analgesic in the world. Paracetamol is commonly taken in overdose either deliberately or unintentionally. In high-income countries, paracetamol toxicity is a common cause of acute liver injury. There are various interventions to treat paracetamol poisoning, depending on the clinical status of the person. These inter...
متن کاملColorimetry of serum acetaminophen (paracetamol) in uremia.
A popular colorimetric analysis for serum acetaminophen, based on ring-nitration of the drug, is demonstrated to yield both "false positives" and erroneously high results for serum from uremic patients. The interference appears to be anionic at physiological pH, and correlates significantly with serum creatine concentration and with the magnitude of the "anion gap." A modification of the analys...
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Investigation of analgesic activity with oral administration of ethanol (CSE3) and aqueous (CES4) Cassia siamea extracts showed a dose-dependent profile similar with morphine in albinos Wistar rats. And ip injection of 1ml/kg of naloxone, a specific antagonist of morphine, 45 min after oral administration of extracts at the effective dose of 200 mg/kg completely reversed the analgesic effect. H...
متن کاملA risk-benefit assessment of paracetamol (acetaminophen) combined with caffeine.
OBJECTIVE To determine the risk: benefit of paracetamol combined with caffeine in the short-term management of acute pain conditions. DESIGN Database searches were conducted to identify double-blind trials comparing paracetamol/caffeine with paracetamol alone (benefit analysis) and any data pertaining to hepatotoxicity of paracetamol when combined with caffeine (risk analysis). INTERVENTION...
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ژورنال
عنوان ژورنال: Pediatric Anesthesia
سال: 2008
ISSN: 1155-5645,1460-9592
DOI: 10.1111/j.1460-9592.2008.02764.x