PAPP-A: a new anti-aging target?

PAPP‐A: a promising therapeutic target for healthy longevity

Pregnancy-associated plasma protein-A (PAPP-A) is a proteolytic enzyme that was discovered to increase local insulin-like growth factor (IGF) availability for receptor activation through cleavage of inhibitory IGF binding proteins (IGFBPs). Reduced IGF signaling has been associated with increased lifespan and healthspan. Therefore, inhibition of PAPP-A represents a novel approach to indirectly ...

A New Modified Particle Filter With Application in Target Tracking

The particle filter (PF) is a novel technique that has sufficiently good estimation results for the nonlinear/non-Gaussian systems. However, PF is inconsistent that caused mainly by loss of particle diversity in resampling step and unknown a priori knowledge of the noise statistics. This paper introduces a new modified particle filter called adaptive unscented particle filter (AUPF) to overcome th...

Drosophila nervous system as a target of aging and anti-aging interventions

1 Institute of Molecular and Cellular Biology, Siberian Branch of Russian Academy of Sciences, Novosibirsk, Russia, Department of Cytology and Genetics, Novosibirsk State University, Novosibirsk, Russia, 3 Institute of Biology of Komi Science Center of Ural Branch of Russian Academy of Sciences, Syktyvkar, Russia, Moscow Institute of Physics and Technology, Dolgoprudny, Russia, 5 Engelhardt Ins...

In Vitro Evaluations for a New Topical Anti-Aging Formulation

The study aimed to evaluate the in vitro properties of a new gel formulation (P-3086) as anti-aging treatment. Two in vitro methods aimed to assess and compare the efficacy of the gel formulation in reducing oxidative damages, artificially induced by UVA on skin-derived keratinocytes and in promoting the synthesis of collagen, compared with other four formulations. P-3086 reduced reactive oxyge...

A new perspective on the determinants of the concept of aging: a letter to the editor