Papillomavirus transcripts and posttranscriptional regulation

Posttranscriptional Regulation of Intrinsic Plasticity

Cell-specific posttranscriptional regulation of CFTR gene expression via influence of MAPK cascades on 3'UTR part of transcripts.

Expression of the cystic fibrosis (CF) transmembrane conductance regulator (CFTR) gene, which contains the mutations responsible for CF, is regulated by cytokines (TNF-alpha and IL-1beta) in a cell-specific manner. TNF-alpha decreases CFTR mRNA in human colon cell lines (HT-29), but not in pulmonary cell lines (Calu-3), and IL-1beta increases it only in Calu-3 cells. We looked for the cytokine-...

Posttranscriptional Expression Regulation: What Determines Translation Rates?

Recent analyses indicate that differences in protein concentrations are only 20%-40% attributable to variable mRNA levels, underlining the importance of posttranscriptional regulation. Generally, protein concentrations depend on the translation rate (which is proportional to the translational activity, TA) and the degradation rate. By integrating 12 publicly available large-scale datasets and a...

Posttranscriptional regulation of lung elastin production.

Elastin is a resilient connective-tissue protein present in the extracellular matrix of most vertebrate tissues, but because of its unique elastomeric properties, this connectivetissue component is especially abundant in the interstitium of tissues that undergo repetitive physical deformations, such as the walls of alveoli and blood vessels (1). Elastic fibers are assembled extracellularly and ...

Regulation of Vascular Function on Posttranscriptional Level

Posttranscriptional control of gene expression is crucial for regulating plurality of proteins and functional plasticity of the proteome under (patho)physiologic conditions. Alternative splicing as well as micro (mi)RNA-mediated mechanisms play an important role for the regulation of protein expression on posttranscriptional level. Both alternative splicing and miRNAs were shown to influence ca...