Pantoprazole pharmacokinetics in obese children: normalized to lean or ideal weight?

Pharmacokinetics of Antimicrobials in Obese Children.

INTRODUCTION Childhood obesity is common and results in substantial morbidity. The most commonly prescribed drugs in obese children are antibiotics. However, physiologic changes associated with childhood obesity can alter antibiotic pharmacokinetics and optimal body size measures to guide dosing in his population are ill defined. This combination can result in therapeutic failures or drug-relat...

Efficacy and pharmacokinetics of pantoprazole in alpacas.

BACKGROUND Despite frequent clinical use, information about the pharmacokinetics and efficacy of pantoprazole in camelids is not available. OBJECTIVES To examine the pharmacokinetics of both IV and SC pantoprazole and to determine whether pantoprazole administration would increase 3rd compartment pH in alpacas. ANIMALS Six healthy adult alpacas. METHODS Alpacas were fitted with a 3rd comp...

Evaluation of electrocardiogram changes in obese children and comparing it with normal weight children

Meal-induced thermogenesis in lean and obese prepubertal children.

The resting metabolic rate (RMR) and the thermic effect of a meal (TEM) were measured in a group of 16 prepubertal (8.8 +/- 0.3 y) obese children (43.6 +/- 9.2 kg) and compared with a group of 10 age-matched (8.6 +/- 0.4 y), normal-weight children (31.0 +/- 6.0 kg). The RMR was higher in the obese than in the control children (4971 +/- 485 vs 4519 +/- 326 kJ/d, P < 0.05); after the RMR was adju...

Energy expenditure in children of lean and obese parents.

We evaluated whether children of obese parents have defects in energy expenditure in a study of 73 children (5 +/- 0.9 yr of age) of lean and obese parents. Total energy expenditure (TEE) was measured over 14 days by use of doubly labeled water and physical activity energy expenditure (AEE) derived by subtracting resting energy expenditure (REE) under postprandial conditions. Fat and fat-free m...