Pancreatic β-cell rescue in diabetes by targeting Merlin
نویسندگان
چکیده
منابع مشابه
miR-494 protects pancreatic β-cell function by targeting PTEN in gestational diabetes mellitus
Gestational diabetes mellitus (GDM) is one of the most common pregnancy complications characterized by insulin resistance and pancreatic β-cell dysfunction. Increasing evidence suggests that microRNAs (miRNAs) play key roles in the diverse types of diabetes, including GDM. However, the underlying mechanisms remain largely unknown. The purpose of this study is to investigate the role of microRNA...
متن کاملMiR-577 inhibits pancreatic β-cell function and survival by targeting fibroblast growth factor 21 (FGF-21) in pediatric diabetes.
Pancreatic β-cell dysfunction is a central component of the pathogenesis of pediatric diabetes. MicroRNA (miRNA) have become one of the most encouraging and fruitful fields in biological research, and have been implicated as new players in the pathogenesis of diabetes and diabetes-associated complications. The role of miRNA in diabetes begins with the development of pancreatic islets. Fibroblas...
متن کاملPancreatic β-Cell Mass as a Pharmacologic Target in Diabetes
While the prevalence of maternal While the prevalence of diabetes mellitus reaches epidemic proportions, most available treatments still focus on the symptoms of the disease, rather than the underlying pathology. Types 1 and 2 diabetes have in common a deficit in β-cell mass. In type 1 diabetes, auto-immune β-cell destruction leads to an absolute deficit in β-cells, while in type 2 diabetes, in...
متن کاملTargeting β‐cell functions in therapy for type 2 diabetes
Recently, Leahy et al. issued a "consensus statement" in regard to targeting β-cell function in therapy for type 2 diabetes that recommends continued multidisciplinary efforts to realign treatment of type 2 diabetes to preserve β-cell function by early intervention. This might be applicable not only for obese type 2 diabetes in Europe and America, but also for lean type 2 diabetes in Asia. To e...
متن کاملEndoplasmic reticulum stress, pancreatic β-cell degeneration, and diabetes.
Overwhelming of protein folding in the endoplasmic reticulum (ER)--referred to as "ER stress"--activates a set of intracellular signaling pathways termed the unfolded protein response (UPR). Beneficial outputs of the UPR promote adaptation in cells experiencing manageably low levels of ER stress. However, if ER stress reaches critically high levels, the UPR uses destructive outputs to trigger p...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Expert Review of Endocrinology & Metabolism
سال: 2017
ISSN: 1744-6651,1744-8417
DOI: 10.1080/17446651.2017.1294484