Pancreas exocrine replacement therapy is associated with increased survival following pancreatoduodenectomy for periampullary malignancy

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A comprehensive clinicopathological analysis and survival outcome of periampullary cancer following pancreatoduodenectomy

Background: The study was to elucidate the relationships between 20 clinicopathologic factors and survival of patients with periampullary cancer receiving pancreatoduodenectomy (PD) or pylorus-preserving partial pancreatoduodenectomy (PPPD). Methods: The retrospective study recruited 224 patients with periampullary cancer, including duodenal papilla, bile duct and ampullary cancers between Janu...

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Agenesis of dorsal pancreas associated with periampullary pancreaticobiliary type adenocarcinoma.

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Marked Expansion of Exocrine and Endocrine Pancreas With Incretin Therapy in Humans With Increased Exocrine Pancreas Dysplasia and the Potential for Glucagon-Producing Neuroendocrine Tumors

Controversy exists regarding the potential regenerative influences of incretin therapy on pancreatic β-cells versus possible adverse pancreatic proliferative effects. Examination of pancreata from age-matched organ donors with type 2 diabetes mellitus (DM) treated by incretin therapy (n = 8) or other therapy (n = 12) and nondiabetic control subjects (n = 14) reveals an ∼40% increased pancreatic...

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Pancreatic fibrosis correlates with exocrine pancreatic insufficiency after pancreatoduodenectomy.

BACKGROUND Obstruction of the pancreatic duct can lead to pancreatic fibrosis. We investigated the correlation between the extent of pancreatic fibrosis and the postoperative exocrine and endocrine pancreatic function. METHODS Fifty-five patients who were treated for pancreatic and periampullary carcinoma and 19 patients with chronic pancreatitis were evaluated. Exocrine pancreatic function w...

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ژورنال

عنوان ژورنال: HPB

سال: 2019

ISSN: 1365-182X

DOI: 10.1016/j.hpb.2019.10.628