Pancreas cancer, careful improvements and human connections

Human trypsinogens in the pancreas and in cancer.

This study led to the development of monoclonal antibodies and time-resolved immunofluorometric methods recognizing human trypsinogen-1 and -2, respectively. Using these methods in normal sera the concentration of trypsinogen-1 was found to be higher than that of trypsinogen-2. However, in acute pancreatitis the concentration of serum trypsinogen-2 was 50-fold higher than in controls, whereas t...

Improvements in the Preparation of Insulin. Alkaline Extraction of Pancreas.

THE original method for preparing insulin from normal fresh pancreas, worked out by Collip [1923], depended on the extraction of the minced tissue with plain alcohol. Doisy, Somogyi and Shaffer [1923] found that they could obtain considerably larger yields of the active principle by extraction with strongly acid alcohol. The fact that insulin in acid solution is readily adsorbed by a great vari...

Borderline and Unresectable Pancreas Cancer

Expert Panel on Radiation Oncology–Gastrointestinal: William Small Jr, MD; John P. Hayes, MD; W. Warren Suh, MD, MPH; May Abdel-Wahab, MD, PhD; Ross A. Abrams, MD; Nilofer Azad, MD; Prajnan Das, MD; Jadranka Dragovic, MD; Karyn A. Goodman, MD; Salma K. Jabbour, MD; William E. Jones III, MD; Andre A. Konski, MD, MBA, MA; Albert C. Koong, MD, PhD; Rachit Kumar, MD; Percy Lee, MD; Timothy M. Pawli...

Morphological lesions associated with human primary invasive nonendocrine pancreas cancer.

In 227 cases of human pancreas cancer (100 pancreatectomy specimens and 127 autopsies), pancreas duct epithelium not involved by invasive cancer was examined. Pancreas duct epithelium from 100 autopsies of patients with nonpancreatic cancer, matched by age and sex to the pancreas cancer autopsy cases, was used for control studies. The prevalence of squamous metaplasia, pyloric gland metaplasia,...

Exocrine pancreas cancer