Palladium‐Mediated C γ −H Functionalization of Alicyclic Amines

نویسندگان

چکیده

This paper describes a new method for the transannular functionalization of γ-C−H bonds in alicyclic amines to install C(sp3)−halogen, oxygen, nitrogen, boron, and sulfur bonds. The key challenge this transformation is controlling relative rate Cγ−H versus Cα−H functionalization. We demonstrate that selectivity can be achieved by pre-complexation substrate with Pd prior addition oxidant. approach enables use diverse oxidants ultimately various heteroatom functional groups at γ-position high site- diastereoselectivity.

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ژورنال

عنوان ژورنال: Angewandte Chemie

سال: 2021

ISSN: ['1521-3773', '1433-7851', '0570-0833']

DOI: https://doi.org/10.1002/ange.202101782