Palladium-catalyzed direct asymmetric C–H bond functionalization enabled by the directing group strategy
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چکیده
منابع مشابه
Palladium-catalyzed direct functionalization of imidazolinone: synthesis of dibromophakellstatin.
We have examined the direct arylation of imidazolinone (1) with 6 different palladium sources, 15 different phosphine ligands, 12 different bases and 14 different solvent systems. There is no significant difference between using Pd(OAc)2 and Pd(TFA)2. This reaction proceeds less efficiently or reproducibly with Pd2(dba)3/(o-biphenyl)PCy2, O=PCy3, O=PPh3, P(OMe)3, PCy3·HBF4, PCy3, PPBu /DMF, NMP...
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A new Pd-catalyzed reaction for the stereoselective synthesis of cyclopentane-fused benzocyclobutenes is described. These transformations likely proceed via carbamate-directed carbopalladation followed by intramolecular C-H activation of an alkylpalladium intermediate. The mechanistic relationship between these transformations and Pd-catalyzed reactions of gamma-(n-Boc-amino)alkenes with aryl b...
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ژورنال
عنوان ژورنال: Chemical Science
سال: 2020
ISSN: 2041-6520,2041-6539
DOI: 10.1039/d0sc03052j