Palatability Can Drive Feeding Independent of AgRP Neurons
نویسندگان
چکیده
منابع مشابه
Hypothalamic Agrp Neurons Drive Stereotypic Behaviors beyond Feeding
The nervous system evolved to coordinate flexible goal-directed behaviors by integrating interoceptive and sensory information. Hypothalamic Agrp neurons are known to be crucial for feeding behavior. Here, however, we show that these neurons also orchestrate other complex behaviors in adult mice. Activation of Agrp neurons in the absence of food triggers foraging and repetitive behaviors, which...
متن کاملAblation of AgRP neurons impairs adaption to restricted feeding
While the SCN controls the circadian clock, further evidence suggests the existence of a food-entrainable oscillator (FEO) that links behavior to changes in food availability such as during restricted feeding (RF). We found that the activity of AgRP/NPY neurons changed rhythmically during RF suggesting that these neurons are a component of the FEO. We next ablated AgRP/NPY neurons in neonates w...
متن کاملNPY/AgRP neurons are essential for feeding in adult mice but can be ablated in neonates.
Hypothalamic neurons that express neuropeptide Y (NPY) and agouti-related protein (AgRP) are thought to be critical regulators of feeding behavior and body weight. To determine whether NPY/AgRP neurons are essential in mice, we targeted the human diphtheria toxin receptor to the Agrp locus, which allows temporally controlled ablation of NPY/AgRP neurons to occur after an injection of diphtheria...
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Bioenergetics is a subject concerned with the energy involved in making and breaking of chemical bonds in the molecules found in biological organisms. Energy transformation is fundamental to growth, development and metabolism of biological organisms. The ability to harness energy from a variety of metabolic pathways is a property of all living organisms. For a multi-organ system like rodents an...
متن کاملAgRP Neurons Regulate Bone Mass.
The hypothalamus has been implicated in skeletal metabolism. Whether hunger-promoting neurons of the arcuate nucleus impact the bone is not known. We generated multiple lines of mice to affect AgRP neuronal circuit integrity. We found that mice with Ucp2 gene deletion, in which AgRP neuronal function was impaired, were osteopenic. This phenotype was rescued by cell-selective reactivation of Ucp...
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ژورنال
عنوان ژورنال: Cell Metabolism
سال: 2015
ISSN: 1550-4131
DOI: 10.1016/j.cmet.2015.07.011