Paget's Disease — Osteitis Deformans

Studies of Paget's disease (osteitis deformans).

Additional Cases of Osteitis Deformans.

I SHOULD not have offered to the Royal Medical and Chirurgical Society a mere collection of cases such as this paper contains, if it were not for the hope that they may help to clearly indicate the chief characters of the disease to which I venture to give the name of osteitis deformans, and which, so far as I know, was first described in the paper published in the 60th volume of the Society's ...

Heart Block in Osteitis Deformans.

The simian figure of the country gentleman from the north of England, who was Sir James Paget's first reported case (1877) of osteitis deformans, hobbles still through all accounts of this disease: he exemplifies most of the known complications. Paget himself learnt little more from the twenty-two other cases he saw (1882, 1889), and since then a forest of at least 700 articles, covering over 2...

Circulatory dynamics in osteitis deformans.

In Paget's disease the peripheral blood flow is increased in the bones affected by the disease. Nevertheless the circulatory dynamics of the patients studied at rest are usually not modified significantly. But during exercise, an abnormal augmentation of the cardiac output in regard to the metabolic needs is observed. These findings are similar to those the authors have observed in patients suf...

Control of osteitis deformans using glucagon, calcitonin, and mithramycin.

Glucagon, porcine calcitonin, and mithramycin were given to patients with Paget's disease of bone. There was rapid complete relief of bone pain accompanied by biochemical improvement or normalization in all cases. Calcitonin and glucagon appear to have additive properties in Paget's disease and the use of the 3 drugs in combination may reduce the incidence of side effects and the development of...