Paget disease of bone

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Pathology of Paget ’ s disease of bone

Paget’s disease of bone is a common metabolic disorder, which is in most cases diagnosed on the basis of its radiographic findings. Its primary bone alterations and subsequent complications constitute a complex range of pathologic pictures, which may pose diagnostic difficulties upon histologic examination. This article illustrates the spectrum of pathologic features of Paget’s disease of bone ...

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The primary objective of Paget’s disease treatment is the relief of symptoms, but treatment is also commonly prescribed to prevent the development of late complications in asymptomatic subjects with active disease (i.e., above normal serum alkaline phosphatase [bALP]). An aggressive course of treatment is recommended before surgery at the site of a pagetic lesion, the aim being to reduce as muc...

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Introduction: Mammary Paget’s disease is generally accompanied by in situ ductal carcinoma, consequently, prompt diagnosis and treatment can halt further invasion and yield better prognosis. Case Presentation: The patient was a 39-year old woman, who presented with superficial ulcers and nipple discharge of left breast, She had no palpable mass underneath. The patient was G2 P2 and under oral ...

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ژورنال

عنوان ژورنال: Journal of Clinical Investigation

سال: 2005

ISSN: 0021-9738

DOI: 10.1172/jci200524281