PACAP-38 and PACAP(6–38) Degranulate Rat Meningeal Mast Cells via the Orphan MrgB3-Receptor
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چکیده
منابع مشابه
The ATP4- receptor of rat mast cells.
The concentration-dependence on exogenous ATP of activation and inhibition of mast-cell histamine secretion, phosphatidylinositol labelling and leakage of metabolites shows that all these functions are regulated by the free acid ATP4-. Maximal histamine secretion and phosphatidylinositol labelling occur with ATP4- at approx. 2 microM, but higher concentrations, which cause inhibition of secreti...
متن کاملRat mast cells degranulate in response to microinjection of guanine nucleotide.
Investigation of regulated exocytosis has frequently required the use of permeabilised cell preparations. This has provided evidence that Ca2(+)-binding and guanine nucleotide-binding proteins can mediate secretion. Since the manner and extent of membrane permeabilisation affect the requirements for Ca2+ and guanine nucleotide, we have introduced such effectors directly into intact, rat periton...
متن کاملPACAP-38 enhances excitatory synaptic transmission in the rat hippocampal CA1 region.
Specific receptors for pituitary adenylate cyclase-activating polypeptide (PACAP), a novel peptide with neuroregulatory and neurotrophic functions, have been identified recently in different brain regions, including the hippocampus. In this study, we examined the effects of PACAP-38 on the excitatory postsynaptic field potentials (fEPSPs) evoked at the Schaffer collateral-CA1 synapses. Brief ba...
متن کاملPACAP-(1-38) as neurotransmitter in the porcine adrenal glands.
The concentration of pituitary adenylyl cyclase-activating polypeptide [PACAP-(1-38)] in porcine adrenal glands amounted to 14 +/- 3 pmol/g tissue. PACAP immunoreactive (PACAP-IR) fibers innervated adrenal chromaffin cells (often co-localized with choline acetyltransferase). Subcapsular fibers traversed the cortex-innervating endocrine cells and blood vessels [some co-storing mainly calcitonin ...
متن کاملDifferential effects of PACAP-38 on synaptic responses in rat hippocampal CA1 region.
Pituitary adenylate cyclase-activating polypeptide (PACAP-38) is a member of the vasointestinal polypeptide (VIP)/secretin/glucagon family of neuropeptides for which neuroregulatory functions have been postulated. PACAP-38 receptors are expressed in different brain regions, including hippocampus. In this study, we examined the dose-dependent effects of PACAP-38 on the excitatory postsynaptic fi...
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ژورنال
عنوان ژورنال: Frontiers in Cellular Neuroscience
سال: 2019
ISSN: 1662-5102
DOI: 10.3389/fncel.2019.00114