P9‐49: Involvements of endotoxin in airway inflammation of asthma
نویسندگان
چکیده
منابع مشابه
Tanshinone IIA attenuates ovalbumin-induced airway inflammation and hyperresponsiveness in a murine model of asthma
Objective(s): Tanshinone IIA (T. IIA), one of the most pharmacologically active components extracted from Salviae miltiorrhiza, has anti-inflammatory and antioxidant features. The aim of the present study is to investigate the benefit of T. IIA on asthma using a murine model of asthma induced by ovalbumin (OVA). Materials and Methods: Male BALB/c mice were used in the present study. The mice we...
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Asthma was originally described as an inflammatory disease that predominantly involves the central airways. Pathological and physiological evidence reported during the past few years suggests that the inflammatory process extends beyond the central airways to the peripheral airways and the lung parenchyma. The small airways are capable of producing T-helper-2 cytokines, as well as chemokines, a...
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As bronchial asthma is currently considered to be and is defined as being an inflammatory disorder of the airways [1], it seems logical to include an assessment of this inflammation in the diagnosis and follow-up of the disease. In this assessment, a few factors need to be taken into account. Firstly, the inflammation underlying asthma is a complex phenomenon that displays characteristics, not ...
متن کاملConcomitant Exposure to Ovalbumin and Endotoxin Augments Airway Inflammation but Not Airway Hyperresponsiveness in a Murine Model of Asthma
Varying concentrations of lipopolysaccharide (LPS) in ovalbumin (OVA) may influence the airway response to allergic sensitization and challenge. We assessed the contribution of LPS to allergic airway inflammatory responses following challenge with LPS-rich and LPS-free commercial OVA. BALB/c mice were sensitized with LPS-rich OVA and alum and then underwent challenge with the same OVA (10 µg in...
متن کاملDose-dependent activation of lymphocytes in endotoxin-induced airway inflammation.
Recruitment of neutrophils to lung tissue and airspaces is a hallmark of inflammatory events following inhalation of endotoxins. We studied the role of different lymphocyte subsets in this inflammation, which is assumed to primarily involve the innate immune system. Inhalation of aerosolized Escherichia coli lipopolysaccharide (LPS) in mice induced a dose-dependent increase in neutrophils in br...
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ژورنال
عنوان ژورنال: Respirology
سال: 2021
ISSN: ['1440-1843', '1323-7799']
DOI: https://doi.org/10.1111/resp.14150_750