p63 heterozygous mutant mice are not prone to spontaneous or chemically induced tumors
نویسندگان
چکیده
منابع مشابه
p63 heterozygous mutant mice are not prone to spontaneous or chemically induced tumors.
Homology between p63 and p53 has suggested that these proteins might function similarly. However, the majority of data from human tumors have not supported a similar role for p63 in tumor suppression. To investigate this issue, we studied spontaneous tumorigenesis in p63+/- mice in both WT and p53-compromised backgrounds. We found that p63+/- mice were not tumor prone and mice heterozygous for ...
متن کاملLRH-1 heterozygous knockout mice are prone to mild obesity.
Obesity is a global health problem that increases the risk of several common diseases. Liver receptor homologue-1 (LRH-1) has an important role in steroid hormone metabolism, which influences body weight. Whether LRH-1 gene deletion causes obesity is yet to be clarified. In this study using LRH-1 heterozygous knockout (LRH-1(+/-)) mice, we investigated the role of LRH-1 on body weight gain and ...
متن کاملAntibody response of mice to chemically induced tumors.
BALB/c mice immunized with syngeneic methylcholanthrene-induced fibrosarcomas did not have antibodies against the unique tumor-specific transplantation antigens, even though they were capable of rejecting a lethal dose of tumor cells. Endogenous murine leukemia virus antigens expressed by certain of the tumors did, however, elicit high titers of antibodies, accounting for serological crossreact...
متن کاملImmune status of autochthonous and adoptively protected mice toward spontaneous and chemically induced tumors.
mice were used. Autografts of either of these tumors grew better than isografts into normal mice. Attempts to transfer this conditioned status from primary hosts bearing MCA tumors to syngeneic recipients were unsuccessful. Neither with lymphoid cells nor with serum could we induce such state in recipient mice in which latency and growth of primary and transplanted, MCA-induced tumors was measu...
متن کاملHigh incidence of spontaneous and chemically induced liver tumors in mice deficient for connexin32
Connexins are subunits of gap junction channels, which mediate the direct transfer of ions, second messenger molecules and other metabolites between contacting cells. Gap junctions are thought to be involved in tissue homeostasis, embryonic development and the control of cell proliferation [1,2]. It has also been suggested that the loss of intercellular communication via gap junctions may contr...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2006
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0602477103