منابع مشابه
Consistent absence of BRAF mutations in salivary gland carcinomas
Introduction: Malignant salivary gland tumors are rare entities. Despite advances in surgery, radiation therapy and chemotherapy, the rate of the mortality and five-year survival has not been improved markedly over the last few decades. The activation of EGFR- RAS-RAF signaling pathway contributes to the initiation and progression of many human cancers, promising a key pathway for therapeutic m...
متن کاملconsistent absence of braf mutations in salivary gland carcinomas
introduction: malignant salivary gland tumors are rare entities. despite advances in surgery, radiation therapy and chemotherapy, the rate of the mortality and five-year survival has not been improved markedly over the last few decades. the activation of egfr- ras-raf signaling pathway contributes to the initiation and progression of many human cancers, promising a key pathway for therapeutic m...
متن کاملUnique association of p53 mutations with undifferentiated but not with differentiated carcinomas of the thyroid gland.
Thyroid neoplasms show a wide variety of lesions varying from slowly growing differentiated adenocarcinomas to rapidly proliferating undifferentiated carcinomas. There has been some histopathological evidence that the undifferentiated thyroid carcinomas are derived from differentiated carcinomas. Moreover, it is suspected that some genetic events might be associated with such changes. In the pr...
متن کاملConsistent absence of BRAF mutations in salivary gland carcinomas
Introduction: Malignant salivary gland tumors are rare entities. Despite advances in surgery, radiation therapy and chemotherapy, the rate of the mortality and five-year survival has not been improved markedly over the last few decades. The activation of EGFRRAS-RAF signaling pathway contributes to the initiation and progression of many human cancers, promising a key pathway for therapeutic mol...
متن کاملp53 gene mutations in oral carcinomas from India.
In this study, we analyzed 53 oral squamous-cell carcinomas among Indians for the presence of alterations in the tumor-suppressor gene p53 by PCR-SSCP and sequencing methods. Our results showed that 21% (11/53) of oral carcinomas analyzed carried mutations within the exons 5-8 of the p53 gene. We have identified 11 single-base pair substitutions consisting of 10 mis-sense mutations and one at t...
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ژورنال
عنوان ژورنال: International Journal of Cancer
سال: 1998
ISSN: 0020-7136,1097-0215
DOI: 10.1002/(sici)1097-0215(19980504)76:3<317::aid-ijc5>3.0.co;2-y