منابع مشابه
Neddylating the Guardian Mdm2 Catalyzed Conjugation of Nedd8 to p53
The tumor suppressor and transcriptional regulator p53 is perhaps one of the most regulated proteins in the cell nucleus and is acted upon by a variety of protein kinases, acetylases, ubiqutin ligases and hydrolases, and SUMO-conjugating enzymes. Now new work suggests a role for an additional modification-neddylation-in negative regulation of p53 transcriptional activity.
متن کاملGrowth Control: p53, the Guardian Angel of Compensatory Proliferation
Compensatory growth, or regeneration, is used to replace damaged tissue during animal development. Recent work has revealed a new role for Drosophila p53 in the compensatory proliferation of cells that are needed to repair damaged tissues, a role that requires the non-apoptotic function of the caspase protease Dronc.
متن کاملp53 Mutations and DNA Ploidy in Colorectal Adenocarcinomas
The p53 tumour suppressor gene has an important role in the the maintenance of genome stability and its mutational inactivation may be at the origin of aneuploidy in cancer cells. The aim of this study was to determine whether p53 mutations were associated to DNA aneuploidy, as assessed by flow cytometry, in colorectal adenocarcinomas. Analysis of p53 mutations spectrum of the sorted nuclei was...
متن کاملThe Maintenance of Epigenetic States by p53: The Guardian of the Epigenome
Commentary on: Leonova et al. p53 cooperates with DNA methylation and a suicidal interferon response to maintain epigenetic silencing of repeats and noncoding RNAs. PNAS, USA, 2012; in press. The functions of the p53 tumor suppressor gene and its protein are to ensure fidelity of cellular replicative processes so as to minimize mutational errors even in the presence of a wide variety of environ...
متن کاملOncogenic mutations of the p53 tumor suppressor: the demons of the guardian of the genome.
The p53 guardian of the genome is inactivated in the majority of cancers, mostly through missense mutations that cause single residue changes in the DNA binding core domain of the protein. Not only do such mutations result in the abrogation of wild-type p53 activity, but the expressed p53 mutant proteins also tend to gain oncogenic functions, such as interference with wild-type p53-independent ...
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ژورنال
عنوان ژورنال: Molecular Oncology
سال: 2011
ISSN: 1574-7891
DOI: 10.1016/j.molonc.2011.07.007