p53 and p21 Determine the Sensitivity of Noscapine-Induced Apoptosis in Colon Cancer Cells
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چکیده
منابع مشابه
p53 and p21 determine the sensitivity of noscapine-induced apoptosis in colon cancer cells.
We have previously discovered the naturally occurring antitussive alkaloid noscapine as a tubulin-binding agent that attenuates microtubule dynamics and arrests mammalian cells at mitosis via activation of the c-Jun NH(2)-terminal kinase pathway. It is well established that the p53 protein plays a crucial role in the control of tumor cell response to chemotherapeutic agents and DNA-damaging age...
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It is well known that dietary phenolic compounds can elicit vital cellular responses such as cytotoxicity, cell cycle arrest and apoptosis by activating a cascade of molecular events. Ellagic acid is one of these phenolic compounds, but the exact mechanism of its action is still unclear. The objective of this study was to investigate ellagic acid-induced cell cycle arrest and apoptosis in T24 h...
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Mohammad A Khasawneh1*, Adrian Koch4, Hanan M Elwy2, Alaaeldin A Hamza2,3 and Regine Schneider-Stock4 1Department of Chemistry, Faculty of Science U.A.E. University, Al-Ain, P.O. Box 17551, UAE 2National Organizations of Drug Control and Research, 6 Abu Hazem St., Giza, Egypt 3Department of Biology, Faculty of Science U.A.E. University, Al-Ain, P.O. Box 17551, UAE 4Experimental Tumorpathology, ...
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Cancer cells of epithelial and mesenchymal phenotypes exhibit different sensitivities to apoptosis stimuli, but the mechanisms underlying this phenomenon remain partly understood. We constructed a novel recombinant adenovirus expressing Ad12 E1A (Ad-E1A12) that can strongly induce apoptosis. Ad-E1A12 infection of epithelial cancer cells displayed dramatic detachment and apoptosis, whereas cance...
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ژورنال
عنوان ژورنال: Cancer Research
سال: 2007
ISSN: 0008-5472,1538-7445
DOI: 10.1158/0008-5472.can-06-4282