P410 Has body composition any effect on thiopurine level in IBD?
نویسندگان
چکیده
منابع مشابه
Therapeutic drug monitoring of thiopurine metabolites in adult thiopurine tolerant IBD patients on maintenance therapy.
BACKGROUND AND AIMS Therapeutic drug monitoring of active metabolites of thiopurines, azathioprine and 6-mercaptopurine, is relatively new. The proposed therapeutic threshold level of the active 6-thioguanine nucleotides (6-TGN) is ≥235 pmol/8×10(8) erythrocytes. The aim of this prospective cross-sectional study was to compare 6-TGN levels in adult thiopurine tolerant IBD patients with an exace...
متن کاملA practical guide to thiopurine prescribing and monitoring in IBD.
Thiopurines are often the mainstay of treatment for many patients with inflammatory bowel disease. As such, a general understanding of the evidence behind their use and of their metabolism is extremely useful in clinical practice. This review gives a practical overview of thiopurine metabolism, the importance of thiopurine S-methyltransferase testing prior to the start of therapy and the monito...
متن کاملRole of thiopurine metabolite testing and thiopurine methyltransferase determination in pediatric IBD.
Thiopurines have been used in inflammatory bowel disease (IBD) for >30 years, and measurements of both thiopurine methyltransferase (TPMT) and thiopurine (TP) metabolites, 6-thioguanine nucleotides (6-TGN) and 6-methylmercaptopurine (6-MMP), have been readily available. The North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition (NASPGHAN) Committee on Inflammatory Bowe...
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Background: Obesity and infertility have been linked together by several studies. Obesity results in an increased production of estrogen; this hormonal imbalance in turn interferes with ovulation, which of course, is the basis of successful conception. Auricular acupuncture is one of the acupuncture therapies used to prevent and treat obesity. Materials and Methods: In this research we used aur...
متن کاملC-Terminal Propeptide of BKA has a Protease Sensitive Structure Without any Inhibitory Effect on BKA
In our previous study, we compared the two α-amylase enzymes from Bacillus sp.KR8104, BKA∆(N44) and BKA∆(N44C193) which is the secreted form of it. The results indicated that the presence of 193 amino acids propeptide in the C-terminal of BKA∆(N44) changed its enzymatic parameters like an uncompetitive inhibitor in comparison to BKA∆(N44C193). In the present study, we cloned the DNA sequence of...
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ژورنال
عنوان ژورنال: Journal of Crohn's and Colitis
سال: 2018
ISSN: 1873-9946,1876-4479
DOI: 10.1093/ecco-jcc/jjx180.537