P32 Bone inflammation and fever: an atypical presentation of chronic recurrent multifocal osteomyelitis (CRMO)?

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Chronic Recurrent Multifocal Osteomyelitis (CRMO): Presentation, Pathogenesis, and Treatment

PURPOSE OF REVIEW Chronic non-bacterial osteomyelitis (CNO) with its most severe form chronic recurrent multifocal osteomyelitis (CRMO) is an autoinflammatory bone disorder. We summarize the clinical presentation, diagnostic approaches, most recent advances in understanding the pathophysiology, and available treatment options and outcomes in CNO/CRMO. RECENT FINDINGS Though the exact molecula...

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Chronic Recurrent Multifocal Osteomyelitis: A Case Report with Atypical Presentation

INTRODUCTION Chronic recurrent multifocal osteomyelitis (CRMO) is a rare autoinflammatory condition. The clinical picture consists of sterile osteomyelitis, typically with multiple-site lesions in the metaphysis of long bones and not uncommonly, symmetrical bone involvement. It is a poorly understood entity, whose prognosis, etiology and ideal treatment are still controversial. The authors repo...

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Bone scintigraphy in diagnosing chronic recurrent multifocal osteomyelitis

A 10-year-old boy was referred to us for evaluation of FUO accompanied with bone pain in both calves. Three hours after intravenous injection of 13 mCi of 99mTc-MDP, whole body scan in multiple spot views was performed. The scan showed symmetrical areas of diffusely increased tracer uptake in multiple long bones. Histopathologic evaluation confirmed osteosclrosis and fibrotic changes...

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Recurrent multifocal osteomyelitis (CRMO); effect of neridronate

Introduction Chronic recurrent multifocal osteomyelitis (CRMO) is an autoinflammatory bone disease of unknown etiology. Clinically, the disease is characterized by the insidious onset of local pain and swelling in affected bones. Its course is one of intermittent periods of exacerbation and remission with successive bones affected.CRMO most commonly affects the metaphysis of long bones, especia...

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Chronic recurrent multifocal osteomyelitis (CRMO) – advancing the diagnosis

BACKGROUND Chronic recurrent multifocal osteomyelitis (CRMO) is a little known inflammatory bone disease occurring primarily in children and adolescents. Delays in referral and diagnosis may lead to prolonged courses of antibiotics with in-patient care, unnecessary radiation exposure from multiple plain radiographs or bone scans and repeated surgery including bone biopsies. Children (aged < 18 ...

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ژورنال

عنوان ژورنال: Rheumatology

سال: 2018

ISSN: 1462-0324,1462-0332

DOI: 10.1093/rheumatology/key273.034