P3.01-062 Profiling DNA Methylation and Gene Expression on Cancer Stemness Reprogramming in Lung Adenocarcinoma
نویسندگان
چکیده
منابع مشابه
Gene expression profiling analysis of lung adenocarcinoma
The present study screened potential genes related to lung adenocarcinoma, with the aim of further understanding disease pathogenesis. The GSE2514 dataset including 20 lung adenocarcinoma and 19 adjacent normal tissue samples from 10 patients with lung adenocarcinoma aged 45-73 years was downloaded from Gene Expression Omnibus. Differentially expressed genes (DEGs) between the two groups were s...
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The p16 (CDKN2/MTS-1/INK4A) tumor-suppressor gene is frequently inactivated by DNA methylation in lung carcinomas. To clarify whether background anthracosis may play a role in DNA methylation and inactivation of the p16 gene, we examined DNA methylation of the p16-promoter region by methylation-specific polymerase chain reaction, and p16 expression immunohistochemically, and compared the result...
متن کاملEffect of Cold Atmospheric Plasma on Gene Expression and Methylation of Genes Involved in Colorectal Cancer
Background and purpose: Colorectal cancer (CRC) is ranked as the second most common cancer in men and the third most common cancer in women worldwide. Routine treatments have many side effects and little efficiency. The aim of this study was to investigate the effects of Cold Atmospheric Plasma (CAP) on epigenetic changes of some genes involved in CRC progression. Materials and methods: Prolif...
متن کاملGene Methylation Profiling in Sinonasal Adenocarcinoma and Squamous Cell Carcinoma.
OBJECTIVE To identify epigenetic events in intestinal-type sinonasal adenocarcinoma (ITAC) and sinonasal squamous cell carcinoma (SNSCC) and to evaluate their relation to clinicopathologic features and follow-up data. STUDY DESIGN Retrospective study. SETTING Academic research hospital. SUBJECTS AND METHODS The methylation status of 23 genes in 50 ITACs and 32 SNSCCs was analyzed by methy...
متن کاملReveals new lung adenocarcinoma cancer genes based on gene expression.
BACKGROUND Lung adenocarcinoma (LAC) is the most common type of lung cancer, accounting for 30-35% of all cases. AIM In this study we aim to predict potential genes and confirm pathways which are associated with LAC. MATERIALS AND METHODS By using the meta-analysis method, GSE10072 and GSE 2514 datasets were merged to find potential genes and pathways which are associated with LAC. RESULT...
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ژورنال
عنوان ژورنال: Journal of Thoracic Oncology
سال: 2017
ISSN: 1556-0864
DOI: 10.1016/j.jtho.2016.11.1628