P2X7 Receptor Antagonist Attenuates Retinal Inflammation and Neovascularization Induced by Oxidized Low-Density Lipoprotein

Age-related macular degeneration (AMD) is a common and severe blinding disease among people worldwide. Retinal inflammation neovascularization are two fundamental pathological processes in AMD. Recent studies showed that P2X7 receptor was closely involved the inflammatory response. Here, we aim to investigate whether A740003, antagonist, could prevent retinal induced by oxidized low-density lipoprotein (ox-LDL) explore underlying mechanisms. ARPE-19 cells C57BL/6 mice were treated with ox-LDL A740003 successively for vitro vivo studies. In this research, found suppressed reactive oxygen species (ROS) generation inhibited activation of Nod-like pyrin-domain protein 3 (NLRP3) inflammasome nuclear factor-?B (NF-?B) pathway. also angiogenic factors angiogenesis mice. The cytokines phosphorylation inhibitor alpha (IKB?) repressed A740003. Besides, ERG assessment functions remarkably preserved A740003-treated summary, our results revealed antagonist reduced protected function. protective effects associated regulation NLRP3 NF-?B pathway, as well inhibition factors.