P2X3 receptors contribute to transition from acute to chronic muscle pain
نویسندگان
چکیده
منابع مشابه
Pain Modulation and the Transition from Acute to Chronic Pain.
There is now increasing evidence that pathological pain states are at least in part driven by changes in the brain itself. Descending modulatory pathways are known to mediate top-down regulation of nociceptive processing, transmitting cortical and limbic influences to the dorsal horn. However, these modulatory pathways are also intimately intertwined with ascending transmission pathways through...
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متن کاملP2X2/3 and P2X3 receptors contribute to the metaboreceptor component of the exercise pressor reflex.
The exercise pressor reflex is due to activation of thin fiber afferents within contracting muscle. These afferents are in part stimulated by ATP activation of purinergic 2X (P2X) receptors during contraction. Which of the P2X receptors contribute to the reflex is unknown; however, P2X2/3 and P2X3 receptor subtypes are good candidates because they are located on thin fiber afferents and are inv...
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ژورنال
عنوان ژورنال: Purinergic Signalling
سال: 2020
ISSN: 1573-9538,1573-9546
DOI: 10.1007/s11302-020-09718-x