p27kip1: An all-round tumor suppressor

An X-linked tumor suppressor in T-ALL.

In this issue of Blood, Van der Meulen et al demonstrate that the lysine demethylase UTX (also known as KDM6A), best known as an “eraser” of methylation at histone 3 lysine 27 (H3K27), is an X-linked tumor suppressor in T-cell acute lymphoblastic leukemia (T-ALL). This finding is surprising because the biochemical activity of UTX at H3K27 is antagonized by the “writer” methyltransferase EZH2, w...

Relocalized p27Kip1 tumor suppressor functions as a cytoplasmic metastatic oncogene in melanoma.

The p27 tumor suppressor negatively regulates G1 cell cycle progression. However, human malignancies rarely select for deletion/inactivation of p27, a hallmark of tumor suppressor genes. Instead, p27 is degraded or relocalized to the cytoplasm in aggressive malignancies, supporting the notion that p27 sequestration from its nuclear cyclin:cyclin-dependent kinase (cdk) targets is critical. Howev...

TMIGD1 acts as a tumor suppressor through regulation of p21Cip1/p27Kip1 in renal cancer

Renal cell carcinoma (RCC) is a high-risk metastasizing tumor with a poor prognosis and poorly understood mechanism. In this study, we demonstrate that transmembrane and immunoglobulin domain-containing 1 (TMIGD1) is a novel tumor suppressor that is highly expressed in normal renal tubular epithelial cells, but it is downregulated in human renal cancer. We have identified CCAAT/enhancer-binding...

All-round approach in diagnosis

tau.amegroups.com © Translational Andrology and Urology. All rights reserved. Dr. Veeramachaneni (1) in response to the practice recommendations by Agarwal et al. (2) reminded the importance of interacting multiple factors on reproductive system. Indeed, it is of paramount importance to rule out reversible factors (such as genital tract infection and exposure to environmental toxicants) during ...

Calcium--an "all-round player" in the cornea.