P277 A survey of UK cystic fibrosis centres regarding stopping anti-Pseudomonas aeruginosa (PA) nebulised therapy in children who become free from Pa infection

Chronic Pseudomonas aeruginosa (PA) infection in children with cystic fibrosis (CF) has a detrimental effect on morbidity and mortality. There is clear well referenced guidance the diagnostic criteria for chronic PA how to treat it. However, nebulised treatment burdensome guidelines do not advise manage who stop isolating specifically, if should be discontinued. This particularly important era of highly effective CFTR modulator therapy as monitoring lower airways more difficult productive sputum. To assess practice at UK Paediatric CF Centres regarding stopping anti-PA nebs become free from PA. A questionnaire was sent via email clinical lead each 29 Tertiary clarify they consider are so, after what duration. We also asked there were other such patients need meet before treatment. Responses received 23/29 (79%) centres. Of these, 22/23 (96%) child becomes all but one, this specific duration time. three years one centre, two eight centres, 18 months year 10 centres centre. The additional needed achieve varied between included type frequency microbiology samples both stopping, stability patient, mucoid phenotype adherence physiotherapy. majority or years. trials area guide management these children.