P27 Hepatitis B outreach to people who inject drugs (PWID)

to new hepatitis C therapies for people who inject drugs

Hepatitis C virus (HCV) disease progression in people who inject drugs (PWID): A systematic review and meta-analysis.

BACKGROUND Understanding HCV disease progression rates among people who inject drugs (PWID) is important to setting policy to expand access to detection, diagnosis and treatment, and in forecasting the burden of disease. In this paper we synthesize existing data on the natural history of HCV among PWID, including fibrosis progression rates (FPR) and the incidence of compensated cirrhosis (CC), ...

Hepatitis C virus vaccines among people who inject drugs.

Most people who inject drugs (PWID) are infected with hepatitis C virus (HCV), and PWID have the highest risk of HCV infection of any risk group. The incidence of HCV infection is 5%-25% per year, demonstrating continued need for HCV infection prevention in PWID. Existing data in chimpanzees and PWID suggest that protective immunity against persistent HCV infection is achievable. Due to the hig...

Burden of Liver Disease among Community-Based People Who Inject Drugs (PWID) in Chennai, India

BACKGROUND AND OBJECTIVE We characterize the burden of liver disease in a cohort of PWID in Chennai, India, with a high prevalence of HCV. MATERIALS AND METHODS 1,042 PWID were sampled through community outreach in Chennai. Participants underwent fasting blood draw, questionnaire and an examination that included liver stiffness assessment using transient elastography (Fibroscan) and assessmen...

HIV incidence among people who inject drugs (PWID) in Ukraine: results from a clustered randomized trial

BACKGROUND HIV prevalence among people who inject drugs (PWID) in Ukraine is among the highest in the world. In this study, we aimed to assess whether a social network intervention was superior to HIV testing and counselling in affecting HIV incidence among PWID. Although this was not the primary aim of the study, it is associated with reducing drug and sex risk behaviours, which were primary a...