P2.02-018 Genomic Profiling of Driver Gene Mutations in 498 Chinese NSCLC Patients

P02-018 - PSTPIP1 gene mutations in periodic fever patients

Introduction Familial Mediterranean Fever (FMF) is considered a rare disease in Japan. Our institution began screening for MEFV gene mutations in patients with periodic fever in 2005. Among the 18 patients screened, we have identified 11 (56.5%) FMF patients with heterozygous M694I/E148Q mutations. Among the other 7 patients, no pathogenic mutations were detected by the direct sequencing of all...

ROS1 gene rearrangement and clinicopathological characteristics in Chinese NSCLC patients

Objective: Since Rikova et al. reported c-ros oncogene 1 (ROS1) rearrangements in non-small cell lung cancer (NSCLC) in 2007, data on the clinicopathological characteristics of ROS1-positive patients in China are scarce. We aim to examine the correlation between clinicopathological characteristics of NSCLC patients and the frequency of ROS1-rearrangements. Methods: The cancer tissues of 1720 pa...

The correlation between programmed death-ligand 1 expression and driver gene mutations in NSCLC

OBJECTIVES This study aimed to evaluate the correlation between positive PD-L1 expression and driver gene mutations in NSCLC and to seek preliminary evidence in favor of the strategy of PD-L1 inhibitors plus targeted agents. RESULTS The overall analyses revealed that positive PD-L1 expression had a significant relationship with KRAS status (RR = 1.26; 95% CI, 1.06-1.50, P = 0.010), but no cor...

Liquid-Based Cytological Samples for Detecting EGFR Mutations in Chinese Patients with NSCLC

Activating mutations in epidermal growth factor receptor (EGFR) gene confer dramatic sensitivity to EGFR TKIs (Rich et al., 2004). Several large randomized phase III studies consistently showed that EGFR-TKIs, such as gefitinib, erlotinib or afatinib achieved significantly higher response rates and longer progression-free survival (PFS) compared to standard chemotherapy and should be regarded a...

Identification of Mutations in G6PD Gene in Patients in Hormozgan Province of Iran