P2.01-037 Molecular Biology Underlying COPD and Lung Cancer Converge on FOXM1 Network
نویسندگان
چکیده
منابع مشابه
Molecular Biology of Lung Cancer
━━ Recent advances in biotechnology have made it possible to explore the molecular pathogenesis of human lung cancer. Since the 1980s, various alterations, including mutations in the P53 and KRAS genes, allelic alterations like loss of heterozygosity, and DNA methylation of tumor-related genes have been extensively studied. In 2004, epidermal growth factor receptor (EGFR) gene mutation was disc...
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It has been hypothesised that clinically evident lung cancers have accumulated many different genetic or epigenetic abnormalities in oncogenes and/or tumour suppressor genes. This notion has important clinical ramifications. Recent developments in our knowledge of the molecular biology of lung cancer are reviewed, with particular reference to genetic abnormalities in tumour suppressor gene inac...
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We read with interest the recent editorial by Strange (December 2010), 1 who suggests that with a greater understanding of COPD may come a greater understanding of lung cancer biology. Here, we review evidence from recently published genetic epidemiologic studies that supports this view by showing COPD and lung cancer are linked at a molecular genetic level. In 2009, we showed that COPD affects...
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We investigated the transcriptional mechanism underlying lung cancer development. RNA sequencing analysis was performed on blood samples from lung cancer cases and healthy controls. Differentially expressed microRNAs (miRNAs), circular RNAs (circRNAs), mRNAs (genes), and long non-coding RNAs (lncRNA) were identified, followed by pathway enrichment analysis. Based on miRNA target interactions, a...
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BACKGROUND The formation of distant metastases constitutes a complex process with a variety of different genes and pathways involved. To improve patient survival, it is necessary to understand the underlying mechanisms of metastasis to allow for targeted intervention. METHODS This review provides an overview of the general concepts of metastasis, focusing on the most important genes and pathw...
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ژورنال
عنوان ژورنال: Journal of Thoracic Oncology
سال: 2017
ISSN: 1556-0864
DOI: 10.1016/j.jtho.2016.11.1089