P2-383: 18 F-FLORBETABEN AND 18 F-FLUTEMETAMOL PET BETA-AMYLOID BINDING EXPRESSED IN CENTILOIDS WITHOUT CONVERSION TO PIB

Post-mortem histopathology underlying β-amyloid PET imaging following flutemetamol F 18 injection

In vivo imaging of fibrillar β-amyloid deposits may assist clinical diagnosis of Alzheimer's disease (AD), aid treatment selection for patients, assist clinical trials of therapeutic drugs through subject selection, and be used as an outcome measure. A recent phase III trial of [18F]flutemetamol positron emission tomography (PET) imaging in 106 end-of-life subjects demonstrated the ability to i...

[ 18 F ] Fdg - Pet

Separation of β-amyloid binding and white matter uptake of (18)F-flutemetamol using spectral analysis.

The kinetic components of the β-amyloid ligand (18)F-flutemetamol binding in grey and white matter were investigated through spectral analysis, and a method developed for creation of parametric images separating grey and white matter uptake. Tracer uptake in grey and white matter and cerebellar cortex was analyzed through spectral analysis in six subjects, with (n=4) or without (n=2) apparent β...

Amyloid imaging with (18)F-florbetaben in Alzheimer disease and other dementias.

UNLABELLED Amyloid imaging with (18)F-labeled radiotracers will allow widespread use, facilitating research, diagnosis, and therapeutic development for Alzheimer disease. The purpose of the study program was to compare cortical amyloid deposition using (18)F-florbetaben and PET in controls and subjects with mild cognitive impairment (MCI), frontotemporal lobar degeneration (FTLD), dementia with...

Amyloid-β assessed by florbetapir F 18 PET and 18-month cognitive decline: a multicenter study.

OBJECTIVES Florbetapir F 18 PET can image amyloid-β (Aβ) aggregates in the brains of living subjects. We prospectively evaluated the prognostic utility of detecting Aβ pathology using florbetapir PET in subjects at risk for progressive cognitive decline. METHODS A total of 151 subjects who previously participated in a multicenter florbetapir PET imaging study were recruited for longitudinal a...