P149 NFKAPPABAND JNK PATHWAYSMEDIATE THE IL-1β DOWN-REGULATION OF TGFβ TYPE II RECEPTOR
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منابع مشابه
Down-regulation of microRNA-216b inhibits IL-1β-induced chondrocyte injury by up-regulation of Smad3
Osteoarthritis (OA) is the most common type of joint disease, leading to a major cause of pain and disability. OA is characterized by the continuous degradation of articular cartilage, mainly resulting in an imbalance between synthesis and degradation of articular chondrocyte extracellular matrix (ECM). Aberrant miR-216b expression has been found in multiple cancers. However, the level of miR-2...
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We previously showed that interleukin-1 (IL-1 ) down-regulation of type II TGF receptor (T RII) involves NF B pathway and requires de novo synthesis of a yet unknown protein. Here, we demonstrate that this effect is mediated through Sp1 site located at position –25 of human T RII promoter. Inhibition of transcription factors binding (decoy oligonucleotides or mithramycin) abolished IL-1 effect....
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In the immune system, interleukin (IL)-1β effects are mediated by the type I IL-1 receptors (IL-1RI), whereas the type II IL-1 receptors (IL-1RII) act as inhibitory receptors. IL-1RI and IL-1RII are also present in the brain. To study their functionality in the brain, mice were centrally treated with neutralizing monoclonal antibody (MAb) directed against IL-1RI (35F5, 1 μg) or against IL-1RII ...
متن کاملTGFβ (transforming growth factor β) receptor type III directs clathrin-mediated endocytosis of TGFβ receptor types I and II
The TGFβ (transforming growth factor β) pathway is an essential cell signalling pathway that is implicated in both normal developmental processes, such as organogenesis, and pathological disorders, such as cancer and fibrosis. There are three prototypical TβRs (TGFβ receptors): TβRI (TβR type I), TGβRII (TβR type II) and TGFβRIII (TβR type III, also known as betaglycan). Whereas the role of TβR...
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ژورنال
عنوان ژورنال: Osteoarthritis and Cartilage
سال: 2006
ISSN: 1063-4584
DOI: 10.1016/s1063-4584(07)60601-3