P11.43.B The impact of neutrophils-to-lymphocytes ratio on survival in patients affected by brain metastases and treated with Gamma Knife Radiosurgery
نویسندگان
چکیده
Abstract Background The Neutrophil-to-Lymphocyte ratio (NLR) is a biomarker for host systemic inflammation. Elevated NLR may result from neutrophilia, lymphopenia or both and associated with poor prognosis treatment responses in various malignant tumors, such as breast, gastric, colorectal lung cancer. It was found that patients treated GK-SRS brain metastases (BM) non-small cell cancer (NSCLC), median survival significantly longer < 5 at the time of radiosurgery after (within 1 month SRS). High percentage neutrophils, low lymphocytes elevated platelet-to-lymphocyte were predictive OS metastases. Further evidences are needed to support better define these findings. Material Methods We retrospectively examined 111 consecutive BMs NSCLC (95 patients) melanoma (16 GK-SRS. A total 695 lesions (median lesion number per patient 6; range 1-18), volume 0.108 cc (range 0.004-33.44 cc). calculated using N/L, where N L, respectively, refer peripheral blood neutrophils (N) lymphocyte (L) counts timepoint nearest SRS treatment. Kaplan-Meier analysis described according NLR. Univariable multivariable Cox regression analyses used confirm impact on overall survival. Results Median (IQR) age diagnosis 64 yrs (55-70), 6.7 (1.3-32), 13.5 months (1-42). At univariable Cox-regression analyses, lower improved (HR: 1.05; p=0.004). Total lymphocytes, monocytes not (all p>0.1). adjusting age, sex use DEX therapy, represented an independent predictor 1.06; p=0.003). Conclusion represents prognostic factor affected by melanoma. Inflammation immunity play critical role patients. examining more specific subsets increase our understanding etiology progression.
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ژورنال
عنوان ژورنال: Neuro-oncology
سال: 2022
ISSN: ['1523-5866', '1522-8517']
DOI: https://doi.org/10.1093/neuonc/noac174.232