p110α and p110β isoforms of PI3K signaling: are they two sides of the same coin?

Hypoxia and inflammation are two sides of the same coin.

Hypoxia and inflammation share an interdependent relationship (1). Many recent publications implicate hypoxia-elicited inflammation, or inflammation during hypoxic conditions in the outcomes of a wide array of human diseases (2). On the one hand, inflammatory disease states are frequently characterized by tissue hypoxia, or stabilization of hypoxiadependent transcription factors, such as hypoxi...

Are hemostasis and thrombosis two sides of the same coin?

Factor XII (FXII), a clotting enzyme that can initiate coagulation in vitro, has long been considered dispensable for normal blood clotting in vivo because hereditary deficiencies in FXII are not associated with spontaneous or excessive bleeding. However, new studies show that mice lacking FXII are protected against arterial thrombosis (obstructive clot formation) and stroke. Thus, FXII could b...

Copper: two sides of the same coin.

Two sides of the same coin.

Want to get experience? Want to get any ideas to create new things in your life? Read two sides of the same coin now! By reading this book as soon as possible, you can renew the situation to get the inspirations. Yeah, this way will lead you to always think more and more. In this case, this book will be always right for you. When you can observe more about the book, you will know why you need t...

Cancer and neurodegeneration: two sides, same coin?

Two papers just published would at first glance have little in common: one features a novel approach to combating metastases [1] whilst the other suggests a new strategy for treating Alzheimer’s, [2]. Nonetheless, here we describe a possible link based on the concept that both cancer and neurodegeneration are inappropriately activated forms of development, and in both cases could be mediated by...